February 28th, 2011 
admin a trainer told me that mixing it in a shaker can cause the supplement to lose it nitric oxide gas…
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Posted in Nitric Oxide 
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mixing in a closed container or shaker makes more sense because theres nowhere for the gas to escape… i mean seriousl its not rocket science to figure that out…
Yeah it does. It specifically says on the container DO NOT SHAKE. I always mix mine with a spoon.
I’ve copied and pasted this from other questions as I’m tired of typing it out each time, some helpful things you may want to know before taking this supplement:
nitric oxide is used in the body as a chemical messenger. As it relates to your workout, the body uses it for a signal in the endothelial layer of your blood vessels to relax smooth muscle resulting in vasodilation (expansion) of the blood vessels. This results in increased blood flow to the muscles and all organs in general. The most notable are the heart and brain. A direct downside to this is in formation of platelet clots specifically from internal bleeding. Nitric oxide should not be sent through the blood in large quantities when activating the intrinsic pathway. Short term side effects are serious if internal bleeding occurs
It also has severe oxidative effects which will take some time to develop, but will arise. Until recently it was believed nitric oxide produces excessive stress on the mitochondrial protein DRP-1 by mechanism I won’t explain here. This creates the neuro-degeneration associated with Alzheimers Disease.
Now it is known the DRP-1 specific Alzheimer mechanism is false. But it has been proven without a doubt nitrosative stress-induced mitochondrial fragmentation (oxidation of mitochondria in the brain by nitric oxide) is highly associated with Alzheimers disease.
Honestly from my experience it varies on the product/brand. For example, with NO-Xplode, you need to use a spoon, if you use a shaker it will feel like it is going to explode from all the gas trapped. If you use Bulldozer XL5000, you can use a spoon or a shaker since it reacts and mixes differently.
Overall, I prefer you test it out. Most Pre workout and Intra workout products are designed to be safe in a shaker because as an intra workout product you need to consume it during your workout.
my personal preference is using a shaker. Sometimes I would mix Bulldozer XL in Gatorade bottle, drink half before the gym, and the remaining I would sip throughout my workout
Good luck